The Priebbenow Research Group is focused on the discovery of new modes of chemical reactivity that enable the development of useful chemical reactions for the synthesis and manufacture of new pharmaceuticals or agrochemicals.

Our research predominantly focuses on transition-metal catalysed C-H activation processes and the use of light to drive new chemical reactions.

Prospective students and industry partners should contact Dan to discuss available funding or research opportunities.

Dr Daniel Priebbenow completed his PhD in Synthetic Organic Chemistry at Deakin University (Australia) under the supervision of A/Prof Fred Pfeffer (Deakin University) and A/Prof Scott Stewart (University of Western Australia). Dan was subsequently awarded an Alexander von Humboldt Fellowship within the group of Prof. Dr. Carsten Bolm at the Institute of Organic Chemistry, RWTH Aachen University (Germany). Dan is currently an Australian Research Council (ARC) DECRA Research Fellow based in the School of Chemistry at the University of Melbourne (Australia).

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Transition Metal Catalysis & C-H Activation

Our focus in this area is on the use of organosilicon-derived directing groups for C-H functionalisation processes such as olefination, allylation and hydroarylation. To achieve such transformations we are exploring the use of a variety of rhodium, ruthenium, iridium and cobalt-based catalytic systems.

Photochemistry

Synthetic photochemistry employs light irradiation to electronically excite molecules, which leads to  novel activation modes, reactive intermediates and mechanistic pathways. Our focus in this area is the use of light to drive chemical reactions using two different approaches: (A) photons absorbed by photosensitisers that can subsequently activate reactants through energy transfer or electron transfer processes; and (B) photons absorbed by the reactants, whereby specific functional groups such as acyl silanes can be directly excited to generate reactive carbene intermediates.

(32) Intramolecular Photochemical [2+1]-Cycloadditions of Nucleophilic Siloxy Carbenes
Amanda Bunyamin, Carol Hua, Anastasios Polyzos and Daniel L. Priebbenow*
Chemical Science, 2022, accepted manuscript.

(31) Acyl Silane Directed Cp*Rh(III)-Catalysed Alkylation/Annulation Reactions
Daniel L. Priebbenow*, Carol Hua
Chemical Communications, 2021, 57, 7938–7941

(30) Synthesis and Evaluation of Pyridine-Derived Bedaquiline Analogues Containing Modifications at the A-Ring Subunit
Lisa Barbaro, Gayathri Nagalingam, James A. Triccas, Lendl Tan, Nicholas P. West, Jonathan B. Baell* and Daniel L. Priebbenow*
RSC Medicinal Chemistry, 2021, 12,  943–959.

(29) Fluorinated Ketones as Trapping Reagents for Visible-Light-Induced Singlet Nucleophilic Carbenes
Daniel L. Priebbenow*, Rowan Pilkington, Kyle N. Hearn and Anastasios Polyzos
Organic Letters, 2021, 23, 2783–2789

(28) Discovery of Potent and Fast-Acting Antimalarial Bis-1,2,4-triazines
Daniel L. Priebbenow, Mitch Mathiew, Da-Hua Shi, Jitendra R. Harjani, Julia G. Beveridge, Marina Chavchich, Michael D. Edstein, Sandra Duffy, Vicky M. Avery, Robert T. Jacobs, Stephen Brand, David M. Shackleford, Wen Wang, Longjin Zhong, Given Lee, Erin Tay, Helena Barker, Elly Crighton, Karen L. White, Susan A. Charman, Amanda De Paoli, Darren J. Creek, and Jonathan B. Baell*
Journal of Medicinal Chemistry, 2021, 64, 4150–4162

(27) Silicon-Derived Singlet Nucleophilic Carbene Reagents in Organic Synthesis
Daniel L. Priebbenow*
Advanced Synthesis & Catalysis, 2020, 362, 1927–1946

(26) Discovery of Acylsulfonohydrazide-Derived Inhibitors of the Lysine Acetyltransferase, KAT6A, as Potent Senescence-Inducing Anti-Cancer Agents
Daniel L. Priebbenow, David J. Leaver, Nghi Nguyen, Benjamin Cleary, H. Rachel Lagiakos, Julie Sanchez, Lian Xue, Fei Huang, Yuxin Sun, Prashant Mujumdar, Ramesh Mudududdla, Swapna Varghese, Silvia Teguh, Susan A. Charman, Karen L. White, David M. Shackleford,
Kasiram Katneni, Matthew Cuellar, Jessica M. Strasser, Jayme L. Dahlin, Michael A. Walters, Ian P. Street, Brendon J. Monahan, Kate E. Jarman, Helene Jousset Sabroux, Hendrik Falk, Matthew C. Chung, Stefan J. Hermans, Natalie L. Downer, Michael W. Parker, Anne K. Voss, Tim Thomas, and Jonathan B. Baell*
Journal of Medicinal Chemistry, 2020, 63, 4655–4684

(25) Insights into the Stability of Siloxy Carbene Intermediates and their Corresponding Oxocarbenium Ions
Daniel L. Priebbenow*
The Journal of Organic Chemistry, 2019, 84, 11813–11822

(24) Discovery of Benzoylsulfonhydrazides as Potent Inhibitors of the Histone Acetyltransferase KAT6A
David J. Leaver, Benjamin Cleary, Nghi Nguyen, Daniel L. Priebbenow, H. Rachel Lagiakos, Julie Sanchez, Lian Xue, Fei Huang, Yuxin Sun, Prashant Mujumdar, Ramesh Mudududdla, Swapna Varghese, Silvia Teguh, Susan A. Charman, Karen L. White, Kasiram Katneni, Matthew Cuellar, Jessica M. Strasser, Jayme L. Dahlin, Michael A. Walters, Ian P. Street, Brendon J. Monahan, Kate E. Jarman, Helene Jousset Sabroux, Hendrik Falk, Matthew C. Chung, Stefan J. Hermans, Michael W. Parker, Tim Thomas and Jonathan B. Baell*
Journal of Medicinal Chemistry, 2019, 62, 7146–7159

(23) Substituted Pyridazin-3-(2H)-ones as Highly Potent and Biased Formyl Peptide Receptors
Girdhar Singh Deora, Cheng Xue Qin, Elizabeth A. Vecchio, Aaron J. Debono, Daniel L. Priebbenow, Ryan M. Brady, Julia Beveridge, Silvia C. Teguh, Minh Deo, Lauren T. May, Guy Krippner, Rebecca H. Ritchie and Jonathan B. Baell*
Journal of Medicinal Chemistry, 2019, 62, 5242–5248

(22) New synthetic approaches towards analogues of bedaquiline
Daniel L. Priebbenow*, Lisa Barbaro and Jonathan Baell*
Organic & Biomolecular Chemistry, 2016, 14, 9622–9628

(21) Regio- and Stereo-selective Iodoacyloxylations of Alkynes
Daniel L. Priebbenow*, Robert W. Gable and Jonathan Baell*
The Journal of Organic Chemistry, 2015, 80, 4412–4418

(20) Iron‐Catalyzed Acylative Dealkylation of N‐Alkylsulfoximines
Philip Lamers, Daniel L. Priebbenow and Carsten Bolm*
European Journal of Organic Chemistry, 2015, 5594–5602

(19) The Synthesis of Chiral Benzothiazine and Thiazinoquinoline Derivatives.
Long Wang, Daniel L. Priebbenow, Xiao-Yun Chen, Fang-Fang Pan and Carsten Bolm*
European Journal of Organic Chemistry, 2015, 3338–3343

(18) N-Arylations of Sulfoximines with 2-Arylpyridines by Copper-Mediated Dual N-H/C-H Activation
Long Wang, Daniel L. Priebbenow, Wanrong Dong and Carsten Bolm*
Organic Letters, 2014, 16, 2661–2663

(17) C–H Activation of Methylarenes in the MnO₂-Mediated Aroylation of N-Chlorosulfoximines
Daniel L. Priebbenow and Carsten Bolm*
Organic Letters, 2014, 16, 1650–1652

(16) Photochemical Intramolecular Silylacylations of Electron-Deficient Internal Alkynes
Peter Becker, Daniel L. Priebbenow, Hui-Jun Zhang, Ramona Pirwerdjan and Carsten Bolm*
The Journal of Organic Chemistry, 2014, 79, 814–817

(15) Copper-Catalyzed Oxidative Decarboxylative Couplings of Sulfoximines and Aryl Propiolic Acids
Daniel L. Priebbenow, Peter Becker and Carsten Bolm*
Organic Letters, 2014, 15, 6155–6157

(14) Acylsilanes in Rh(III)-Catalyzed Directed Aromatic C-H Alkenylations and Siloxycarbene Reactions with C-C Double Bonds
Peter Becker, Daniel L. Priebbenow, Ramona Pirwerdjan and Carsten Bolm*
Angewandte Chemie International Edition, 2014, 53, 269–271

(13) Exploring the Reactivity of N-Alkynylated Sulfoximines:  [2+2] Cycloadditions
Ramona Pirwerdjan, Daniel L. Priebbenow, Peter Becker, Philip Lamers and Carsten Bolm*
Organic Letters, 2013, 15, 5397–5399

(12) Acylsilanes: Valuable Organosilicon Reagents in Synthetic Chemistry
Hui-Jun Zhang, Daniel L. Priebbenow and Carsten Bolm*
Chemical Society Reviews, 2013, 42, 8540–8571

(11) Recent Advances in the Willgerodt-Kindler Reaction
Daniel L. Priebbenow and Carsten Bolm*
Chemical Society Reviews, 2013, 42, 7870–7880

(10) Copper-Catalyzed Synthesis of α-Thioaryl Carbonyl Compounds through S–S and C–C Bond Cleavage
Liang-Hua Zou, Daniel L. Priebbenow, Long Wang, Jakob Mottweiler and Carsten Bolm*
Advanced Synthesis & Catalysis, 2013, 355, 2558–2563

(9) The Di-Substitution of Acetals to Prepare Bis(Aryl) α-Ketoesters
Daniel L. Priebbenow, Liang-Hua Zou, Peter Becker and Carsten Bolm*
European Journal of Organic Chemistry, 2013, 19, 3965–3969

(8) The Copper-Catalyzed Oxidative N-Acylation of Sulfoximines
Long Wang, Daniel L. Priebbenow, Liang-Hua Zou and Carsten Bolm*
Advanced Synthesis & Catalysis, 2013, 355, 1490–1494

(7) The Rhodium-Catalysed Synthesis of Pyrrolidinone-Substituted (Trialkylsilyloxy)acrylic Esters
Daniel L. Priebbenow and Carsten Bolm*
RSC Advances, 2013, 3, 10318–10322

(6) Copper-Catalyzed Oxidative Cross-Couplings of Sulfoximines and Alkynes
Long Wang, He Huang, Daniel L. Priebbenow, Fang-Fang Pan and Carsten Bolm*
Angewandte Chemie International Edition, 2013, 52, 3478–3480

(5) Mild Copper-Mediated Direct Oxidative Cross-Couplings of 1,3,4-Oxadiazoles with Polyfluoroarenes Using Dioxygen as Oxidant
Liang-Hua Zou, Jakob Mottweiler, Daniel L. Priebbenow, Jun Wang, Jan A. Stubenrauch and Carsten Bolm*
Chemistry ‑ A European Journal, 2013, 19, 3302–3305

(4) Asymmetric Induction in Domino Heck-aza-Michael Reactions
Daniel L. Priebbenow, Scott G. Stewart* and Frederick M. Pfeffer*
Tetrahedron Letters, 2012, 53, 1468–1471

(3) A One-pot, Three-component Approach to Functionalized Tetrahydroisoquinolines Using Domino Heck-aza-Michael Reactions
Daniel L. Priebbenow, Frederick M. Pfeffer* and Scott G. Stewart*
European Journal of Organic Chemistry, 2011, 9, 1632–1635

(2) A General Approach to N-Heterocyclic Scaffolds using Domino Heck-aza-Michael Reactions
Daniel L. Priebbenow, Scott G. Stewart* and Frederick M. Pfeffer*
Organic & Biomolecular Chemistry, 2011, 9, 1508–1515

(1) Domino Heck‑aza-Michael Reactions: Efficient Access to 1-Substituted Tetrahydro-beta-carbolines
Daniel L. Priebbenow, Luke C. Henderson, Frederick M. Pfeffer* and Scott G. Stewart*
The Journal of Organic Chemistry, 2010, 75, 1787–1790

Prospective industry partners or academic collaborators should contact Dan at daniel.priebbenow@unimelb.edu.au for information on potential funding opportunities and projects.

Postgraduate research students (PhD or MSc) wishing to undertake a research project under the supervision of Dr Daniel Priebbenow should send a CV and academic transcript to Dan and apply directly through the University of Melbourne website (click here for PhD or MSc)